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Journal: Regenerative Therapy
Article Title: Sex as a biological variable in human dental pulp stem cells: An exploratory epigenomic and transcriptomic comparison
doi: 10.1016/j.reth.2026.101117
Figure Lengend Snippet: Bulk RNA-seq of human DPSCs from male and female donors. (A) Principal component analysis of rlog-normalized counts for the top 500 most variable genes with concentration eclipses showing within-group dispersion. Each point represents one donor. (B) Pairwise sample–sample correlation matrix between male (M) and female (F) DPSCs. Colors show Pearson correlation coefficients. (C) Unsupervised hierarchical clustering heatmap of all expressed genes using Euclidean distance and complete linkage. (D) Summary of differentially expressed genes (DEGs) in male DPSCs compared to female DPSCs. Outer circles show totals at adjusted p value < 0.05, and inner circles show the subset with |log 2 FC| > 1. (E) MA plot showing sex-biased gene expression in DPSCs. Statistically significant DEGs (adjusted p < 0.05) are marked in green, blue, and red for autosomal, X-linked, and Y-linked genes, respectively. (F) Volcano plot of RNA-seq data with represented genes labelled.
Article Snippet:
Techniques: RNA Sequencing, Concentration Assay, Dispersion, Gene Expression
Journal: iScience
Article Title: BNC2 as a putative transcriptional coordinator linking energy state to neural circuits
doi: 10.1016/j.isci.2026.115733
Figure Lengend Snippet: Regional heterogeneity of Bnc2 mRNA abundance in the mouse brain Quantitative analysis of Bnc2 expression levels (normalized transcripts per million, nTPM) across distinct brain regions, sourced from The protein atlas bulk RNA-seq dataset. Anatomical structures are color-coded and grouped into major divisions: cerebral cortex, olfactory bulb, hippocampal formation, amygdala, basal ganglia, thalamus, hypothalamus, midbrain, pons and medulla, cerebellum, and corpus callosum (white matter). Bars represent the mean nTPM value, and dots indicate individual sample replicates, demonstrating expression variability within each region. Data are presented as mean ± SD.
Article Snippet: We thank the Allen Institute for Brain Science for providing open access to the Mouse Whole-Brain Transcriptomic Cell Type Atlas (MERFISH, Allen Brain Cell Atlas; knowledge.brain-map.org ), and the
Techniques: Expressing, RNA Sequencing, Olfactory